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Home to nine of the ten Fortune 500 companies based in Missouri, the metro area counts among its major corporations Anheuser-Busch, Express Scripts, Centene, Boeing Defense, Emerson, Energizer, Panera, Enterprise, Peabody Energy, Ameren, Post Holdings, Monsanto, Edward Jones, Go Jet, Purina, Olin Corporation, and Sigma-Aldrich. Their major regional center was at Cahokia Mounds, active from 900 to 1500. Louis boundaries, the city was nicknamed as the "Mound City".The city has also become known for its growing medical, pharmaceutical, and research institutions, including as Washington University in St. These mounds were mostly demolished during the city's development.
The Chouteau brothers gained a monopoly from Spain on the fur trade with Santa Fe.In hindsight, many of these original settlers thought of these first few years as "the golden age of St. By 1765, the city began receiving visits from representatives of the English, French, and Spanish governments. Louis became the capital of, and gateway to, the new territory. Many other explorers, settlers, and trappers (such as Ashley's Hundred) would later take a similar route to the West. Louis was incorporated as a city in 1822, and continued to develop largely due to its busy port and trade connections.The Indians in the area expressed dissatisfaction at being under the control of British forces. Shortly after the official transfer of authority was made, the Lewis and Clark Expedition was commissioned by President Thomas Jefferson. Louis in May 1804 along the Missouri River to explore the vast territory. The city elected its first municipal legislators (called trustees) in 1808. Louis in 1818, improving connections with New Orleans and eastern markets. Slaves worked in many jobs on the waterfront as well as on the riverboats. The city had an estimated 2018 population of 302,838 and is the cultural and economic center of the St. The Missouri River merges with the Mississippi River just north of the city, forming the fourth-longest river system in the world.