We addressed this question using an event-related functional magnetic resonance imaging (f MRI) memory suppression task coupled with overnight consolidation, which included memory acquisition, TNT and post-scan testing phases (Fig. During the acquisition phase, participants were trained to remember two sets of associations between faces and aversive scenes on two consecutive days, which occurred about 24 h and 30 min before f MRI scanning.
First, we examined physiological responses associated with suppression of aversive memories before and after overnight consolidation.Here we report that consolidated aversive memories retain their emotional reactivity and become more resistant to suppression.Suppression of consolidated memories involves higher prefrontal engagement, and less concomitant hippocampal and amygdala disengagement.(g) Bar graphs depict suppression scores for both newly acquired and overnight consolidated aversive memories. *PTo further examine the neural representations associated with individual memories before and after overnight consolidation, we implemented a novel analytic approach based on multivariate pattern dissimilarity of item-specific neural activity.We show that aversive memories after overnight consolidation become more resistant to suppression, as evidenced by less suppression-induced forgetting and enduring SCR levels.